Process for production of ioversol

Details Process for production of ioversol Process for production of ioversol

C - Chemistry, Metallurgy

07

C

C07C 237/46 (2006.01) C07C 231/12 (2006.01) C07C 231/24 (2006.01)

Patent

CA 2074946

ABSTRACT A process for the production of N,N'-bis(2,3- dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6- triiodoisophthalamide wherein a mixture of an extraction solvent and 5-[N-(2-acetoxyethyl)acetoxyacetamido]-N,N'- bis(2,3-diacetoxypropyl)-2,4,6-triiodoisophthalamide (hexaacetate) is distilled to remove the extraction solvent, at least a part of which is distilled as an azeotrope with water, so that a solvent exchange is effected to produce a mixture of hexaacetate in water. Hydrolysis of hexaacetate produces the desired product.

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