Process for production of phenylalkanoic acid amide compound...

C - Chemistry – Metallurgy – 07 – C

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C07C 231/10 (2006.01) C07C 233/31 (2006.01) C07C 233/51 (2006.01) C07C 235/34 (2006.01) C07D 263/42 (2006.01)

Patent

CA 2336033

An easy and simple process for the preparation of phenylalkanoic acid amides having excellent germicidal activities; and intermediates therefor. Specifically, a process for the preparation of phenylalkanoic acid amides represented by general formula [3], (wherein X is hydrogen, alkyl, alkoxy, haloalkyl, or halogeno; n is an integer of 1 to 3, with the proviso that when n is 2 or above, Xs may be the same or different from each other; and Y and Z are each independently halogeno or hydrogen), characterized by reacting a carboxylic acid represented by general formula [1], (wherein X, n, Y and Z are each as defined above) with a dehydrating agent to form an oxazolinone represented by general formula [2], (wherein X, n, Y and Z are each as defined above), and reacting this oxazolinone with methyllithium or methylmagnesium halide.

L'invention concerne un procédé facile et simple pour l'élaboration d'amides d'acide phénylalcanoïque, qui ont d'excellents effets germicides, et des intermédiaires correspondants. Spécifiquement, l'invention concerne un procédé relatif à l'élaboration d'amides d'acide phénylalcanoïque de formule générale (3). Dans ladite formule, X est hydrogène, alkyle, alcoxy, haloalkyle ou halogéno; n est un entier valant entre 1 et 3, à condition que si n vaut 2 ou plus, les X peuvent être identiques ou différents; et Y et Z sont chacun indépendamment halogéno ou hydrogène. Ce procédé est caractérisé par la réaction entre un acide carboxylique de formule (1), dans laquelle X, n, Y et Z sont tels que définis ci-dessus, et un agent de déshydratation pour former une oxazolinone de formule générale (2), dans laquelle X, n, Y et Z sont tels que définis ci-dessus, et par la réaction entre cette oxazolinone et un halogénure de méthyllithium ou de méthylmagnésium.

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