C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/70 (2006.01) C07K 14/245 (2006.01) C12N 15/12 (2006.01) C12N 15/19 (2006.01) C12N 15/71 (2006.01)
Patent
CA 2438074
Vectors for producing polypeptides heterologous to prokaryotes are described comprising, along with the polypeptide-encoding nucleic acid, anti-termination nucleic acid that inhibits intragenic transcription termination with a non- lambda promoter therefor and/or nucleic acid encoding a GreA or GreB protein and a promoter therefor. Also described are processes for producing a heterologous polypeptide in prokaryotic host cells utilizing such elements to improve the quality and/or quantity of heterologous polypeptide produced.
L'invention concerne des vecteurs destinés à produire des polypeptides hétérologues dans des procaryotes comprenant, outre l'acide nucléique de codage du polypeptide, un acide nucléique d'antiterminaison qui inhibe la terminaison de transcription intragénique avec un promoteur non lambda de celui-ci et/ou un acide nucléique codant une protéine GreA ou GreB et un promoteur de celui-ci. L'invention concerne également des procédés de production d'un polypeptide hétérologue dans des cellules hôtes procaryotes utilisant ces éléments en vue d'améliorer la qualité et/ou la quantité de polypeptide hétérologue produite.
Paegle Eriks Sasha
Reilly Dorothea
Yansura Daniel G.
Genentech Inc.
Smart & Biggar
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