Process for production of sulfoxide proton pump inhibitors...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2516600

The present invention provides a process for producing sulfoxide derivatives or salts thereof in the amorphous state with reductions in time, cost and environmental impact. The process for the production of sulfoxide derivatives or salts thereof in the amorphous state comprises heat-drying solvated crystals of a sulfoxide derivative or a salt thereof represented by the general formula (I): wherein R1 is hydrogen, methoxy, or difluoromethoxy; R2 is methyl or methoxy; R3 is 3-methoxypropoxy, methoxy, or 2,2,2-trifluoroethoxy; R4 is hydrogen or methyl; and B is hydrogen, alkali metal or 1/2 alkaline earth metal. The sulfoxide derivatives or salts thereof in the amorphous state may be used as medical drugs. (see formula I)

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