C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/279.4
C07D 401/12 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) C07D 207/00 (2006.01) C07D 207/273 (2006.01) C07D 211/00 (2006.01) C07D 211/90 (2006.01) C07D 401/00 (2006.01)
Patent
CA 1273931
A B S T R A C T The present invention relates to the dextrorotatory, optical isomer of diastereomer A of (+)-2,6-dimethyl-4- (m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester, the pharmaceutically acceptable acid addition salts thereof, and a process for their preparation. The process comprises reacting a levorotatory, optical isomer or a racemate of 5-methoxycarbonyl-2,6-dimethyl-4(m-nitrophenyl)-1,4-dihydro- pyridine-3-carboxylic acid or a reactive derivative thereof, with a levorotatory, optical isomer or a racemate of 1- benzyl-3-hydroxy-pyrrolidine. The compound of this invention is useful as a blood vessel dilator.
492966
Arima Hideki
Isomura Yasuo
Okada Minoru
Schmiegel Klaus K.
Tamazawa Kazuharu
Eli Lilly And Company
Johnson Douglas S. Q.c.
Yamanouchi Pharmaceutical Co. Ltd.
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