Process for production of vaccines

Details Process for production of vaccines Process for production of vaccines

A - Human Necessities

61

K

A61K 39/08 (2006.01) C07K 14/33 (2006.01)

Patent

CA 2737403

The invention relates to a process for the production of a vaccine against bacterial pathogens which produce an AB toxin, like Clostridium, comprising (a) culturing the pathogen under conditions where the AB toxin is produced, and harvesting the culture (b) cleaving the AB toxin enzymatically in vitro, preferably using inositol hexaphosphate as a co-factor, and (c) combining the composition of step (b) with a pharmaceutically acceptable carrier.

L'invention concerne un procédé de production d'un vaccin contre des pathogènes bactériens produisant une toxine AB, telle que Clostridium, qui comprend les étapes consistant à: (a) cultiver le pathogène dans des conditions permettant de produire la toxine AB, et récolter la culture; (b) couper enzymatiquement in vitro la toxine AB, de préférence à l'aide d'inositol hexaphosphate comme cofacteur; et (c) combiner la composition obtenue à l'étape (b) avec un excipient pharmaceutiquement acceptable.

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