C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/113 (2006.01) C07K 1/14 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 14/81 (2006.01)
Patent
CA 2227318
Disclosed is a quick and efficient refolding process which utilizes cellulosic rolled stationary phase to rapidly separate the reduced, denatured protein from the denaturant solution, thereby promoting high protein refold yields at higher protein concentrations, while significantly decreasing the volume needed to achieve protein refolding.
La présente invention concerne un processus rapide et efficace de repliement faisant appel à une phase stationnaire enroulée cellulosique afin de séparer rapidement la protéine réduite dénaturée de la solution dénaturante. Ce processus permet d'obtenir des taux élevés de repliement de protéine dans des concentrations importantes de protéines, tout en réduisant sensiblement le volume nécessaire pour effectuer un repliement des protéines.
Ladisch Michael R.
Seely Robert J.
Amgen Inc.
Gowling Lafleur Henderson Llp
Purdue Research Foundation
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