C - Chemistry – Metallurgy – 11 – C
Patent
C - Chemistry, Metallurgy
11
C
C11C 3/00 (2006.01) A61K 31/337 (2006.01) A61K 47/10 (2006.01) A61K 47/44 (2006.01) C08G 65/26 (2006.01) C08G 65/30 (2006.01) C11B 3/10 (2006.01)
Patent
CA 2347097
A process for purifying a non-ionic surfactant or solvent capable of dispersing and solubilizing a pharmaceutical compound. In the process, a solution of solvent and alcohol is contacted with an activated carbon column and an ion exchange resin column. The process is particularly adapted to the purification of polyethoxylated castor oils. The purified solvent is useful in the preparation of pharmaceutical compositions having enhance shelf life, such as for use with paclitaxel.
L'invention concerne un procédé de purification d'un tensioactif ou d'un solvant non ionique capable de disperser et de solubiliser un composé pharmaceutique. Le procédé selon l'invention consiste à mettre en contact une solution de solvant et d'alcool avec une colonne de charbon actif et une colonne échangeuse d'ions. Le procédé est particulièrement adapté à la purification d'huile de ricin polyéthoxylée. Le solvant purifié s'utilise dans la préparation de compositions pharmaceutiques à longue durée de conservation telles que le paclitaxel.
Ben Venue Laboratories Inc.
Borden Ladner Gervais Llp
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