C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/51 (2006.01) A61K 39/29 (2006.01) C07K 1/16 (2006.01) C07K 14/02 (2006.01) C12N 1/06 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2164672
A process for purifying hepatitis B viral surface antigen comprising the preS2 peptide from the cells of a recombinant organism is carried out by a sequence of steps which includes the step of disrupting the cells using a buffer containing a chaotropic salt to obtain a cell homogenate and the step of alkalifying the cell homogenate to a pH ranging from 11.0 to 13.5.
Kwon Young-Sun
Lee Young-Mee
Lim Kook-Jin
Park Soon-Jae
Yoon Kyung-Hee
Cassan Maclean
Lg Chemical Ltd.
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