Process for purifying recombinant human serum albumin

Details Process for purifying recombinant human serum albumin Process for purifying recombinant human serum albumin

C - Chemistry, Metallurgy

12

N

C12N 15/14 (2006.01) A61K 38/38 (2006.01) C07K 1/36 (2006.01) C07K 14/765 (2006.01)

Patent

CA 2157219

The invention provides a process for purifying recombinant human serum albumin (rHSA) by heating a culture medium containing rHSA and the rHSA-producing host cells, feeding said heated solution upwardly into a fluidized bed in which adsorbent particles are suspended to effect contacting with the adsorbent particles and then recovering the adsorbed fraction containing the rHSA, and a composition comprising rHSA which shows a A350/A280 ratio of below 0.015, when formulated into a 25 % solution of said albumin.

L'invention concerne un procédé de purification de l'albumine sérique humaine recombinante (ASHr) dans lequel on chauffe un milieu de culture contenant l'ASHr et des cellules hôte produisant l'ASHr, on alimente vers le haut un lit fluidisé de ladite solution chauffée qui entrera en contact avec des particules adsorbantes en suspension, puis on récupère la fraction adsorbée contenant l'ASHr. La composition comprenant l'ASHr présente un ratio A350/A280 inférieur à 0,015, lorsqu'elle est formulée en une solution de ladite albumine à 25 %.

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