Process for quinoline-3-carboxylic acid antibacterial agents

Details Process for quinoline-3-carboxylic acid antibacterial agents Process for quinoline-3-carboxylic acid antibacterial agents

C - Chemistry, Metallurgy

07

D

260/270, 260/283

C07D 215/56 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 471/08 (2006.01) C07D 487/02 (2006.01) C07D 487/08 (2006.01) C07D 487/10 (2006.01)

Patent

CA 1277661

ABSTRACT An improved process for the preparation of 7- substituted amino-1-cyclopropyl-6,8 difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acids is described where an alkyl ester of a 6,7,8-trifluoro precursor is converted to a trialkylsilyl ester which fluorine at C7 is directly displaced to the desired product.

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