C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/13, 530/3.08
C07K 14/565 (2006.01) A61K 38/21 (2006.01) C07K 1/113 (2006.01)
Patent
CA 1340586
An approved procedure for the purification and renaturation of biologically active, bacterially produced IFN-beta is described. The partially purified material obtained by solubilization of isolated refractile bodies from the recombinant cells is treated to obtain reduction of the protein in the presence of a chaotropic environment and then oxidized after removal of the reducing agent. However, the chaotropic environment is retained during the oxidation. Upon removal of the chaotropic environment, a solubilizing additive is supplied to maintain the IFN-beta in solution. Further purification by conventional means may also be effected.
578236
Hershenson Susan
Shaked Ze'ev
Thomson Jody
Borden Ladner Gervais Llp
Cetus Corporation
Hershenson Susan
Shaked Ze'ev
Thomson Jody
LandOfFree
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