Process for recovering microbially produced interleukin-2

Details Process for recovering microbially produced interleukin-2 Process for recovering microbially produced interleukin-2

C - Chemistry, Metallurgy

12

N

530/13, 195/72,

C12N 15/26 (2006.01) C07K 1/113 (2006.01) C07K 14/55 (2006.01)

Patent

CA 1335925

A process for recovering substantially pure rIL-2 from transformed microorganisms in which the cells are disrupted, impure insoluble rIL-2 is separated from the bulk of the cellular components, the separated impure rIL-2 is solubilized and partially purified in a reduced form, the solubilized rIL-2 is oxidized, the oxidized rIL-2 is purified to clinically acceptable levels, and the oxidized, purified IL-2 is denatured by placing it into a solution of a chaotropic agent, solids are removed from the solution and rIL-2 is renatured from the solution.

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