Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol...

C - Chemistry – Metallurgy – 07 – C

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C07C 29/09 (2006.01) C07C 29/10 (2006.01) C07C 29/124 (2006.01) C07C 31/38 (2006.01) C07C 43/12 (2006.01)

Patent

CA 2512384

Provided is a process of obtaining 1,1,1,3,3,3-hexafluoro-2-propanol ("HFIP") from a composition comprising an HFIP hydrolyzable precursor. The HFIP hydrolyzable precursor is a compound, other than sevoflurane itself, that has an intact 1,1,1,3,3,3-hexafluoroisopropoxy moiety[(CF3)2CHO~], and contains one or more moieties susceptible to acidic hydrolysis, such that HFIP is released upon such treatment. The process is useful, among other things, for recovering HFIP from waste streams associated with the synthesis of the inhalation anesthetic, fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether ("sevoflurane"). The process includes heating the composition with a strong protic acid to a temperature effective to hydrolyze at least some of the HFIP hydrolyzable precursor to HFIP, and then isolating the HFIP from the heated composition.

L'invention concerne un procédé d'obtention de 1,1,1,3,3,3-hexafluoro-2-propanol ("HFIP") à partir d'une composition contenant un précurseur hydrolysable par HFIP. Le précurseur hydrolysable par HFIP est un composé, autre que le sevoflurane lui-même, qui présente une fraction 1,1,1,3,3,3-hexafluoroisopropoxy intacte [(CF¿3?)¿2?CHO?], et il contient une ou plusieurs fractions susceptibles d'une hydrolyse acide, de telle sorte que le HFIP est libéré lors d'un tel traitement. Le procédé est utile, entre autre, dans la récupération de HFIP dans des flux résiduels associés à la synthèse de fluorométhyl 2,2,2-trifluoro-1-(trifluorométhyl)éthyl éther ("sevoflurane") anesthésique par inhalation. Le procédé consiste à chauffer la composition avec un acide protique fort à une température efficace pour hydrolyser au moins une partie du précurseur hydrolysable par HFIP en HFIP et ensuite à isoler le HFIP de la composition chauffée.¿

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