Process for reducing intraocular pressure

Details Process for reducing intraocular pressure Process for reducing intraocular pressure

A - Human Necessities

61

K

167/234

A61K 31/425 (2006.01) A61K 31/41 (2006.01) A61K 31/63 (2006.01) C07D 285/135 (2006.01)

Patent

CA 1193546

ABSTRACT OF THE DISCLOSURE Process and composition for reducing intraocular pressure and reducing aqueous humor formation by applying topically to the cornea an effective amount of an aqueous solution of a carbonic anhydrase inhibitor comprising a sulfonamide having the following properties: a. sufficiently soluble in water to form at least a 3mM solution at pH of 8.2 or pKa of not greater than 7.3; b. ether partition coefficient of at least 1.0; c. chloroform partition coefficient of at least 0.01; d. dissociation constant against carbonic anhydrase of not more than 3x10-8 molar; e. first order rate constant for penetration of the sulfonamide through a living rabbit cornea of at least 0.005 hr-1; f. not injurious to the cornea; and g. stable in aqueous solution and in contact with the cornea.

380546

Affiliated with

Also associated with

Rating

Process for reducing intraocular pressure does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for reducing intraocular pressure, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for reducing intraocular pressure will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1171519