Process for reducing methionine sulfoxide residues

Details Process for reducing methionine sulfoxide residues Process for reducing methionine sulfoxide residues

C - Chemistry, Metallurgy

07

K

530/1.02, 530/7.

C07K 1/02 (2006.01) C07K 1/06 (2006.01) C07K 1/12 (2006.01)

Patent

CA 1315482

X-6851 Abstract of the Disclosure This application discloses a process for reducing methionine sulfoxide residues in peptides and proteins to methionine residues. The process comprises subjecting said peptide or protein to a substantially anhydrous trifluoroacetic acid reaction medium con- taining from about 0.01M to about 3M of an organic sulfide and from about 0.01M to about 3M of a haloacid selected from the group consisting of hydrochloric acid, hydrobromic acid, and hydroiodic acid.

574821

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