Process for regioselective diol mono-tosylation using...

C - Chemistry – Metallurgy – 07 – C

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C07C 303/28 (2006.01) C07C 309/73 (2006.01)

Patent

CA 2668508

The present invention concerns the use of dibutyl tin oxide for regioselective catalytic diol mono-tosylat ion at a concentration lower than 2 mol%. The present invention also concerns the use of a generic acetal compound of Formula (Ic) in a catalytic process for regioselective diol mono-tosylat ion, wherein Y is selected from the group of C1-6alkyl, phenyl and benzyl. The concentration of the generic acetal compound of Formula (Ic) is less than about 2 mol%, preferably ranges between about 2 mol% and about 0.0005 mol%, preferably ranges between about 0.1 mol% and about 0.005 mol%.

L'invention concerne l'utilisation d'oxyde de dibutyle-étain pour la mono-tosylation catalytique régiosélective de diol à une concentration inférieure à 2 % mol. L'invention concerne également l'utilisation d'un composé acétal générique de formule (1c) dans un procédé catalytique de mono-tosylation régiosélective de diol, Y étant choisi parmi C1-6alkyle, phényle et benzyle. La concentration du composé acétal générique de formule (1c) est inférieure à environ 2 % mol., de préférence comprise entre environ 2 % mol. et environ 0,0005 % mol., notamment comprise entre environ 0,1 % mol. et environ 0,005 % mol.

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