Process for removing waste pox, alendronate and its by-products

Details Process for removing waste pox, alendronate and its by-products Process for removing waste pox, alendronate and its by-products

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) C02F 1/52 (2006.01)

Patent

CA 2191772

Disclosed is a process for removing by-product phosphorus-containing (POx) materials, alendronate and alendronate by-products from crude mother liquors in an omega amino-1-hydroxy-C2-C6 alkylidene-1,1-bisphosphonic acid synthesis process, e.g., alendronate sodium. Calcium chloride is added first to the crude mother liquors, then calcium oxide to precipitate the POx materials, then neutralized to about pH 7 to complete precipitation. Substantially all of the alendronate sodium active ingredient is removed from the precipitate. Following filtration, the POx filtercake can then be disposed of by incineration, landfilling or reclamation of usable phosphorus as fertilizer. The remaining filtrate can then be further treated in an environmentally acceptable manner by wastewater treatment or recycling to the process.

L'invention concerne un procédé pour extraire les matières à base de phosphore (PO¿x?), l'alendronate et les sous-produits d'alendronate à partir de solutions-mères brutes dans un processus de synthèse de l'acide oméga amino-1-hydroxy-C¿2?-C¿6? alkylidène-1,1-bisphosphonique, par exemple, de sodium d'alendronate. On ajoute d'abord du chlorure de calcium aux solutions-mères brutes, puis de l'oxyde de calcium pour assurer la précipitation des matières contenant du PO¿x?, et on effectue ensuite une neutralisation à un pH d'environ 7, pour terminer la précipitation. La totalité de l'ingrédient actif i.e. sodium d'alendronate, pratiquement, est extraite du précipité. Après filtration, le gâteau de filtration de PO¿x? peut être éliminé par incinération, mise en décharge ou récupération du phosphore pouvant être utilisé comme engrais. Le filtrat restant peut être ensuite traité de manière écologique par un système de traitement des eaux usées ou de recyclage.

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