Process for resolving 1-azabicyclo[2.2.1]heptane-3-carboxylates

Details Process for resolving 1-azabicyclo[2.2.1]heptane-3-carboxylates Process for resolving 1-azabicyclo[2.2.1]heptane-3-carboxylates

C - Chemistry, Metallurgy

07

D

260/270, 260/272

C07D 471/08 (2006.01) C07D 453/02 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2016707

T1055Y ABSTRACT Title: PROCESS FOR RESOLVING 1-AZABICYCLO[2.2.1 HEPTANE-3-CARBOXYLATES A process for preparing a substantially pure enantiomer of a 1-azabicyclo[2.2.1]heptane, 1- azabicyclo[3.2.1] octane or quinuclidine, substituted on the carbon atom .beta. to the ring nitrogen by a carboxy group, by synthesising and separating diastereomeric derivatives thereof wherein the hydroxy group of the carboxy is replaced by a residue of a chiral amine or .alpha.-amino acid.

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