Process for resolving the enantiomers of a benzopyran...

C - Chemistry – Metallurgy – 07 – D

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260/279.4

C07D 401/04 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2009924

Abstract The invention relates to a process for resolving the enantiomers of trans-3-hydroxy-3,4-dihydro 2,2- dimethyl-4-(2-oxo-1,2-dihydropyridin-1-yl)-2H-1-benzo- pyran-6-carbonitrile (I), characterized in that racemic I, together with a small amount of (-)-I [or (+)-I], is dissolved in an inert solvent or solvent mixture, the solution is seeded with (-)-I [or (+)-I], the (-)-I [or (+)-I] which has precipitated is isolated, further racemic I is dissolved in the filtrate, the mixture is seeded with (+)-I [or (-)-I], the (+)-I [or (-)-I] which has precipitated is isolated, and if desired this crys- tallization cycle is repeated once or several times.

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