Process for screening substances having a modulating effect...

Details Process for screening substances having a modulating effect... Process for screening substances having a modulating effect...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/66 (2006.01)

Patent

CA 2163549

A process is disclosed for screening substances having a modulating effect on the interleukine-5-receptor-dependent signal transmission path in mammal cells. Test substances are applied on cells which express the functional interleukine-5-receptor and are transformed with a recombinant DNA containing a reporter gene and a regulatory sequence functionally linked thereto which is sensitive to a change in concentration of a secondary messenger substance of the interleukine-5-receptor-dependent signal transmission path. Substances specific to the interleukine-5-receptor-dependent signal transmission path and with potential pharmacological effect may be identified by this process.

L'invention concerne un procédé de criblage de substances à effet modulateur sur la voie de transmission de signaux dépendant d'un récepteur à l'interleukine 5. Des substances d'essai sont appliquées sur des cellules qui expriment le récepteur fonctionnel à l'interleukine 5 et qui sont transformées avec un ADN recombiné, contenant un gène rapporteur et une séquence régulatrice qui y est liée de manière fonctionnelle et qui réagit à la modification de concentration d'un agent messager secondaire de la voie de transmission de signaux dépendant d'un récepteur à l'interleukine 5. Le procédé de criblage permet d'identifier des substances à effet pharmacologique potentiel, qui ont une spécificité pour la voie de transmission de signaux dépendant d'un récepteur à l'interleukine 5.

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