Process for screening substances with a modulating effect on...

Details Process for screening substances with a modulating effect on... Process for screening substances with a modulating effect on...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/53 (2006.01) C12N 15/62 (2006.01) C12Q 1/02 (2006.01) C12Q 1/44 (2006.01) C12Q 1/527 (2006.01) C12Q 1/66 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2122356

2122356 9311257 PCTABS00022 A process is disclosed for screening substances having a modulating effect on a receptor-dependent signal transmission path in mammal cells. Test cells are used transformed with a reporter gene and with a regulatory sequence functionally linked thereto sensitive to the IP3/DAG concentration, as well as with a coding DNA for a receptor coupled to the phospholipase effector system, in particular a G protein-coupled receptor. The use of reference cells without receptor ADN and reference cells with specificity for the adenylate cyclase effector system allows substances to be identified having potential pharmacological action and specificity for a determined receptor-dependent signal transmission path.

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