Process for selective lactonization

Details Process for selective lactonization Process for selective lactonization

C - Chemistry, Metallurgy

07

D

C07D 307/30 (2006.01) A61K 31/366 (2006.01) A61P 3/06 (2006.01) C07D 309/30 (2006.01)

Patent

CA 2342361

A process for the lactonization of compounds of general formula (1) which makes it possible to suppress the formation of dimmers difficultly removable by conventional crystallization purification. Specifically, a compound of general formula (2) having a dimmer content of 0.3 mole % or below is prepared by lactonizing the corresponding compound of general formula (1) under such conditions that the solubility of the compound (1) and/or the compound (2) is 0.5 w/w% or below.

L'invention porte sur un procédé de lactonisation sélective de composés de la formule générale (1), qui permet d'empêcher la formation de dimères difficiles à éliminer par un procédé classique du purification par cristallisation. Plus particulièrement, un composé de la formule générale (2) présentant une teneur en dimère d'au plus 0,3 mole pour cent est préparé par lactonisation du composé correspondant de la formule générale (1) dans des conditions telles que la solubilité du composé (1) et/ou du composé (2) représente au plus 0,5 % en poids.

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