Process for selective peptide bond cleavage

Details Process for selective peptide bond cleavage Process for selective peptide bond cleavage

C - Chemistry, Metallurgy

07

K

530/3.08

C07K 1/12 (2006.01)

Patent

CA 1303793

Abstract of the Disclosure This application describes a process for selectively cleaving a peptide or protein at one or more of its tryptophan residues. The process comprises treating in trifluoroacetic acid said peptide or protein at a concentration of from about 0.05 mM to about 50 mM with an organic sulfoxide at a concentration of from about 0.01M to about 1M, chloride ion at a concentra- tion of from about 0.01M to about 2M, and water at a concentration not in excess of about 10M.

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