C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/6512 (2006.01) A61K 31/216 (2006.01) A61K 31/675 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07C 205/56 (2006.01) C08G 73/02 (2006.01) C07K 5/00 (2006.01)
Patent
CA 2667231
The present invention relates to novel processes for selectively localizing active ingredients both on and in mitochondria within living cells, and to corresponding active ingredients which can penetrate into cells through the cell membrane without further assistants and are localized there selectively both on and in mitochondria. These active ingredients are substituted by at least one monohydroxymononitrophenyl radical or monohydroxydinitrophenyl radical.
La présente invention concerne de nouveaux procédés de localisation sélective de substances actives aussi bien sur que dans des mitochondries dans des cellules vivantes, ainsi que les substances actives correspondantes, lesdites substances actives étant introduites sans autre adjuvant au travers de la membrane cellulaire dans des cellules et localisées de manière sélective aussi bien sur que dans les mitochondries. Ces substances actives sont substituées par au moins un radical monohydroxy-mononitro-phényle ou un radical monohydroxy-dinitro-phényle.
Lindhorst Thomas
Piper Stefan
Werner Birgit
Macrae & Co.
Ugichem Gesellschaft Fuer Organische Chemie Mbh
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