Process for selectively producing 1-phosphorylated sugar...

Details Process for selectively producing 1-phosphorylated sugar... Process for selectively producing 1-phosphorylated sugar...

C - Chemistry, Metallurgy

07

F

C07F 9/655 (2006.01) C07H 1/02 (2006.01) C07H 11/04 (2006.01) C07H 13/08 (2006.01) C07H 19/00 (2006.01) C07H 19/10 (2006.01) C07H 19/12 (2006.01) C07H 19/20 (2006.01) C07H 19/23 (2006.01) C12P 19/38 (2006.01)

Patent

CA 2366513

A mixture of 1-phosphorylated sugar derivative anomers is phosphorolyzed and isomerized to thereby crystallize one of the anomers. Thus, the equilibrium is shifted and a desired isomer alone is selectively produced. From the 1- phosphorylated sugar derivative thus obtained and a base, a nucleoside is produced at a high stereoselectivity and a high yield under the action of a nucleoside phosphorylase. Thus, a process for anomer-selectively producing a 1- phosphorylated sugar derivative and a process for producing a nucleoside are provided.

Selon l'invention, un mélange d'anomères dérivés d'un sucre 1-phosphorylé est phosphorylé et isomérisé afin de cristalliser un des anomères, ce qui permet de déplacer l'équilibre et de produire sélectivement un isomère unique désiré. A partir du dérivé du sucre 1-phosphorylé ainsi obtenu et d'une base, on obtient un nucléoside présentant une stéréosélectivité élevée et un très bon rendement sous l'action d'une nucléoside phosphorylase. L'invention concerne un procédé de production sélective d'un dérivé de sucre 1-phosphorylé avec de l'anomère, et un procédé de production d'un nucléoside.

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