Process for separating 1,2-isopropylideneglycerol benzoyl...

Details Process for separating 1,2-isopropylideneglycerol benzoyl... Process for separating 1,2-isopropylideneglycerol benzoyl...

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) C12M 1/40 (2006.01) C12N 11/04 (2006.01) C12P 17/04 (2006.01)

Patent

CA 2089626

A process is described for separating the optical isomers of 1,2-isopropylideneglycerol, of formula (I), comprising partially stereoselective enzymatic hydrolysis of 1,2-isopropylideneglycerol benzoyl ester (II) catalyzed by a free or immobilized lipase, the hydrolysis being conducted in the presence of a cosolvent and followed by crystallization enabling crystals of (II) in raceme form and mother liquor containing (II) in the form of the pure enantiomer to be selectively obtained. The compound (I) is widely used industrially as an intermediate in the synthesis of chiral drugs such as (R)-(-)-carnitine, (S)-beta-blockers, (S)-antiviral agents, analgesic drugs etc.

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