Process for simvastatin

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 69/732 (2006.01) C07C 67/03 (2006.01) C07D 309/30 (2006.01)

Patent

CA 2067722

120/MW73 18305 TITLE OF THE INVENTION PROCESS TO SIMVASTATIN ABSTRACT OF THE INVENTION A process is disclosed, for the formation of simvastatin, which comprises the sequential acylation of a diol lactone to form a bis acylated intermediate followed by selective deacylation and lactone ring closure to form simvastatin.

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