A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/32 (2006.01) A61K 9/08 (2006.01) A61K 9/48 (2006.01) A61K 31/165 (2006.01) A61K 31/19 (2006.01) A61K 31/405 (2006.01) A61K 31/44 (2006.01) A61K 31/485 (2006.01) A61K 31/60 (2006.01) A61K 47/10 (2006.01)
Patent
CA 2109623
The present invention relates to a process for solubilizing at least one difficultly soluble pharmaceutical active in a mixture of polyethylene glycol and polyvinylpyrrolidone. The process does not require water as a solvent or the use of a heating step. In further embodiments the present invention also relates to a process for encapsulating these solubilized pharmaceutical compositions within soft gelatin shells, which are preferably transparent. Both the resulting compositions and their capsules provide an effective means for oral delivery of a wide variety of difficultly soluble pharmaceutical actives.
Processus de solubilisation d'au moins une matière pharmaceutique active et difficilement soluble, dans un mélange de polyéthylèneglycol et de polyvidone. Ce processus ne nécessite pas l'utilisation d'eau comme solvant, ni une étape de réchauffement. Selon d'autres applications, la présente invention est également liée à un processus d'encapsulation de ces compositions pharmaceutiques solubilisées dans des enveloppes gélatineuses molles, de préférence transparentes. Tant les compositions résultantes que leurs capsules permettent d'administrer oralement de façon efficace une vaste gamme de matières pharmaceutiques actives et difficilement solubles.
Kirby Eades Gale Baker
Richardson Vicks Inc.
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