Process for stereospecific hydrolysis of piperidinedione...

Details Process for stereospecific hydrolysis of piperidinedione... Process for stereospecific hydrolysis of piperidinedione...

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) C07D 211/90 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2135169

2135169 9322284 PCTABS00027 A process for stereospecifically hydrolysing a mixture of the (+) and (-) isomers of a compound of formula (II), in which R is C1-6 alkyl; using a carboxyl esterase enzyme, (i) to form a compound of formula (IIIA), and thereafter separating the resulting compound of formula (IIIA) from the remaining (-) isomer of formula (II); or (ii) to form a compound of formula (IIIB) and thereafter separating the resulting compound of formula (IIIB) from the remaining (+) isomer of formula (II).

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