B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
260/284, 252/65,
B01J 31/30 (2006.01) B01J 31/04 (2006.01) B01J 31/28 (2006.01) C07C 41/01 (2006.01) C07C 43/23 (2006.01) C07C 45/51 (2006.01) C07C 45/61 (2006.01) C07C 45/64 (2006.01) C07C 45/70 (2006.01) C07C 49/84 (2006.01) C07D 215/20 (2006.01) C07D 333/32 (2006.01)
Patent
CA 1164849
A B S T R A C T The invention relates to a process for sub- stituting for a halogen atom attached to the nuclear carbon atom of an aromatic ring, a substituent of the formula -O-R wherein R represents alkyl, alkenyl, alkynyl, or benzyl, which process comprises reacting the halogen-substituted aromatic compound with an alcoholate of the formula Mn+[O-R]? wherein M is an alkali metal atom or alkaline earth metal atom, n is the valency of M, and R is as defined above, in the presence of an active catalyst mixture com- prising (i) formic acid ester of an organic alcohol having the formula R2-O-CO-H wherein R2 is as defined for R above; and (ii) a cuprous salt; in a liquid medium which is a solvent for the catalyst mixture and in which the halogen- substituted aromatic compound is at least partially soluble, under substantially anhydrous conditions and a non-oxidizing atmosphere. The invention further relates to a catalyst used in the above process.
392482
Sanofi-Synthelabo
Smart & Biggar
Sterling Drug Inc.
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