Process for surface modifying substrates and modified...

A - Human Necessities – 61 – L

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A61L 27/34 (2006.01) C08J 7/04 (2006.01) C08J 7/16 (2006.01) G02B 1/04 (2006.01) G02B 1/10 (2006.01)

Patent

CA 2415871

The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double bond to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.

L'invention concerne un procédé de revêtement d'une surface d'une matière, lequel comprend les étapes consistant à: (a) appliquer une couche de liaison comprenant une matière polyionique sur la surface de la matière; (b)à lier par covalence un composé bifonctionnel renfermant une double liaison éthyléniquement insaturée à la couche de liaison; et (c) à effectuer une polymérisation par greffage d'un monomère hydrophile dans le composé comprenant la double liaison éthyléniquement insaturée. Les articles revêtus pouvant être obtenus au moyen du procédé selon l'invention, présentent des caractéristiques recherchées concernant l'adhérence au substrat, la durabilité, l'hydrophilicité, la mouillabilité, la biocompatibilité et la perméabilité et sont, par conséquent, utilisés dans la fabrication d'articles biomédicaux, tels que des dispositifs ophtalmiques.

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