Process for synthesis bis-aryl diamidoxime compounds

Details Process for synthesis bis-aryl diamidoxime compounds Process for synthesis bis-aryl diamidoxime compounds

C - Chemistry, Metallurgy

07

D

C07D 405/00 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2504742

Bis-aryl diamidoxime compounds, such as 2,5-bis [4-hydroxy and 4-O- alkylamidinophenyl] furans, can be prepared from 2,5-bis tri-alkylstannanes via a one step palladium-catalyzed cross reaction. Bis-aryl diamidoxime compounds, such as 2,5-bis [4-hydroxy and 4-0-alkylamidinophenyl] furans, are useful as therapeutic compounds. The disclosed process is scalable, simpler, more economic and more feasible than other presently known methods of preparing 2,5-bis [4-hydroxy and 4-O-alkylamidinophenyl] furans and other bis- aryl diamidoxime compounds.

L'invention concerne des composés bis-aryl diamidoxime tels que des 2,5-bis [4-hydroxy et 4-<I>O</I>-alkylamidinophényl] furanes qui peuvent être préparés à partir de 2,5-bis trialkylstannanes, au moyen d'une réaction croisée catalysée par du palladium et réalisée en une étape. Les composés bis-aryl diamidoxime tels que les 2,5-bis [4-hydroxy et 4-<I>O</I>-alkylamidinophényl] furanes peuvent servir de composés thérapeutiques. Le procédé de préparation selon l'invention est évolutif, plus simple, moins onéreux et plus facile à mettre en oeuvre que les procédés selon l'art antérieur pour préparer des 2,5-bis [4-hydroxy et 4-<I>O</I>-alkylamidinophényl] furanes et d'autres composés bis-aryl diamidoxime.

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