Process for synthesis of amino-methyl tetraline derivatives

Details Process for synthesis of amino-methyl tetraline derivatives Process for synthesis of amino-methyl tetraline derivatives

C - Chemistry, Metallurgy

07

C

C07C 231/06 (2006.01) C07C 231/12 (2006.01) C07C 231/16 (2006.01) C07C 317/32 (2006.01)

Patent

CA 2743978

Methods for producing a compound of formula (k1) or (k2) by reducing a dihydronapthalene amide compound of formula (i); with hydrogen gas in the presence of a ruthenium catalyst of formula (j1) or (j2); Ru(Z)2(L) =(j1), Ru(E)(E')(L)(D) = (j2); wherein m, n, Ar, Y, R1 E, E', D, Z and L are as defined herein.

L'invention concerne des procédés de production d'un composé de formule k1 ou k2 par réduction d'un composé dihydronaphtalène amide de formule i, avec de l'hydrogène gazeux en présence d'un catalyseur au ruthénium de formule j1, Ru(Z)2(L) ou j2, Ru(E)(E')(L)(D), m, n, Ar, Y, R1 E, E', D, Z et L étant tels que définis ici.

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