Process for synthesis of fk-506 and tricarbonyl intermediates

C - Chemistry – Metallurgy – 07 – F

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C07F 7/10 (2006.01) C07C 231/12 (2006.01) C07D 263/26 (2006.01) C07D 339/08 (2006.01) C07D 405/06 (2006.01) C07D 498/08 (2006.01) C07D 498/18 (2006.01) C07F 7/18 (2006.01) C07H 17/08 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2007490

7751P/5495A 6/28/89:F1 17853Y TITLE OF THE INVENTION PROCESS FOR SYNTHESIS OF FK-506 AND TRICARBONYL INTERMEDIATES ABSTRACT OF THE DISCLOSURE A process is described for the total synthesis of the macrolide immunosuppresant, FR-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.

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