C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
260/210, 260/228
C07F 7/10 (2006.01) C07C 231/12 (2006.01) C07D 263/26 (2006.01) C07D 339/08 (2006.01) C07D 405/06 (2006.01) C07D 498/08 (2006.01) C07D 498/18 (2006.01) C07F 7/18 (2006.01) C07H 17/08 (2006.01) C07H 23/00 (2006.01)
Patent
CA 2007490
7751P/5495A 6/28/89:F1 17853Y TITLE OF THE INVENTION PROCESS FOR SYNTHESIS OF FK-506 AND TRICARBONYL INTERMEDIATES ABSTRACT OF THE DISCLOSURE A process is described for the total synthesis of the macrolide immunosuppresant, FR-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.
Askin David
Desmond Richard
Jones Todd K.
Mills Sander G.
Reamer Robert A.
Askin David
Desmond Richard
Gowling Lafleur Henderson Llp
Jones Todd K.
Merck & Co. Inc.
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