Process for synthesis of fk-506 c -c intermediates

Details Process for synthesis of fk-506 c -c intermediates Process for synthesis of fk-506 c -c intermediates

C - Chemistry, Metallurgy

07

D

260/311.6, 260/4

C07D 263/26 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2012885

7538P/5304A 3/23/89:F1 17902 TITLE OF THE INVENTION IMPROVED PROCESS FOR SYNTHESIS OF FK-506 C10-C18 INTERMEDIATES ABSTRACT OF THE DISCLOSURE A process is described for the improved synthesis of the optically pure C10-C18 fragment of the macrolide structure of the immunosuppressant FK-506. This compound is also useful as an intermediate for preparing FK-506 derivatives.

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