Process for synthesizing carbapenem antibiotics

Details Process for synthesizing carbapenem antibiotics Process for synthesizing carbapenem antibiotics

C - Chemistry, Metallurgy

07

D

C07D 477/06 (2006.01) C07D 477/02 (2006.01) C07D 477/20 (2006.01)

Patent

CA 2322658

A process for the direct crystallization of a compound of formula (I) or a pharmaceutically acceptable salt thereof, is disclosed, wherein R1 and R2 represent H, C1-10 alkyl, aryl or heteroaryl, or substituted C1-10 alkyl, aryl or heteroaryl and X+ represents a charge balancing group, comprising extracting a solution containing a crude compound of formula (I) or (Ia) or a pharmaceutically acceptable salt thereof, wherein each X+ is a charge balancing group, and R1 and R2 are as described above with a C4-10 alcohol, collecting and crystallizing the resulting aqueous phase to produce a crystalline compound of formula (I).

L'invention concerne un procédé de cristallisation directe d'un composé de la formule (I) ou d'un sel pharmaceutiquement acceptable dudit composé. Dans ladite formule, R<1> et R<2> sont H, alkyle C1-10, aryle ou hétéroaryle, ou alkyle C1-10 substitué, aryle ou hétéroaryle, et X<+> est un groupe d'équilibrage de charge, le procédé consistant à extraire une solution contenant un composé brut de la formule (I) ou (Ia) ou un sel pharmaceutiquement acceptable dudit composé. Dans lesdites formules, chaque X<+> est un groupe d'équilibrage de charge; R<1> et R<2> sont tels que décrits ci-dessus et contiennent un alcool C4-10, le procédé consistant à recueillir et cristalliser la phase aqueuse résultante pour produire un composé cristallin de la formule (I).

Affiliated with

Also associated with

Rating

Process for synthesizing carbapenem antibiotics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for synthesizing carbapenem antibiotics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for synthesizing carbapenem antibiotics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1740440