Process for synthesizing carbapenem side chain intermediates

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 495/08 (2006.01) C07D 207/16 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2227696

A process of synthesizing a compound of formula (I) is described. A compound of formula (II) is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula (IV). Compound (IV) is then reacted with Na2S in water to produce a compound of formula (I).

La présente invention concerne un procédé de synthèse d'un composé représenté par la formule (I). On fait réagir un composé représenté par la formule (II) avec du chlorure diphénylphosphinique pour rendre actif le groupe acide carboxylique, puis avec du chlorure de méthanesulfonyle pour obtenir un composé représenté par la formule (IV). Ensuite, on fait réagir le composé (IV) avec du Na¿2?S dans l'eau pour produire le composé de la formule (I).

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