Process for the cleavage of cephalosporin prodrug esters to...

Details Process for the cleavage of cephalosporin prodrug esters to... Process for the cleavage of cephalosporin prodrug esters to...

C - Chemistry, Metallurgy

07

D

C07D 501/18 (2006.01) C07D 501/00 (2006.01)

Patent

CA 2096709

The present invention relates to a process for the preparation of 7-amino-3-methoxymethylceph-3-em-4-carboxylic acid (I) from 7-amino-3-methoxymethylceph-3-em-4-carboxylic acid esters (II) or their salts by ester cleavage. The process comprises treating the compound II with formic acid, trifluoroacetic acid, methanesulfonic acid or trifluoromethanesulfonic acid or a mixture of two of these acids in each case.

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