Process for the controlled preparation of low molecular...

Details Process for the controlled preparation of low molecular... Process for the controlled preparation of low molecular...

C - Chemistry, Metallurgy

08

B

167/199, 260/212

C08B 37/08 (2006.01) B01J 19/08 (2006.01) C08B 37/00 (2006.01) C08B 37/10 (2006.01)

Patent

CA 1305134

ABSTRACT A process for the controlled preparation of low molecular weight glucosaminoglycans by treating conventional high molecular weight glucosaminoglycans in the solid state or in solution form with a rectilinear gamma ray beam at doses within the range of 2.5 to 20 Mrad supplied by successive irradiation stages with cooling intervals between one irradiation stage and the next in the dynamic phase. The mixture obtained is subjected to fractionation, purification, neutralisation and lyophilization. The glucosaminoglycans obtained have a molecular weight of between 1000 and 35,000 daltons and are used for the preparation of pharmaceutical compositions possessing antithrombotic, fibrinolytic, antiatherogenic and heparin cofactor II activation activity.

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