C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 265/18 (2006.01)
Patent
CA 2279198
The instant invention describes a method for crystallizing (-)-6-chloro-4- cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one (see formula I) from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40°C and 50°C.
L'invention concerne un procédé permettant de crystalliser du (-)-6-chloro-4-cyclopropyléthynyl-4-trifluorométhyl-1,4-dihydro-2H-3,1-benzoxazine-2-one à partir d'un système de solvant et d'anti-solvant, et de produire le produit cristallin. La forme cristalline finale voulue, forme I, peut être produite lorsqu'on utilise du méthanol ou de l'éthanol. La forme II est isolée à partir de 2-propanol et peut être convertie en la forme cristalline voulue à des températures de séchage peu élevées, telles des températures comprises entre 40 DEG C et 50 DEG C environ.
Clarke William
Crocker Louis S.
Kukura Joseph L. II
Stelmach Christine
Thompson Andrew S.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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