Process for the crystallization of (r)- or (s)-lansoprazole

Details Process for the crystallization of (r)- or (s)-lansoprazole Process for the crystallization of (r)- or (s)-lansoprazole

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 9/50 (2006.01) A61K 31/44 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2436825

The present invention relates to a production method of a crystal of (R)- lansoprazole or (S)-lansoprazole, which includes crystallization at a temperature of about 0(C to about 35(C from a C1-4 alkyl acetate solution containing (R)-lansoprazole or (S)-lansoprazole at a concentration of about 0.1 g/mL to about 0.5 g/mL and the like. According to the production method of the present invention, a crystal of (R)-lansoprazole or (S)-lansoprazole superior in preservation stability can be produced efficiently on an industrial large scale.

L'invention concerne un procédé de fabrication d'un cristal de (R)-lansoprazole ou de (S)-lansoprazole, consistant à cristalliser une solution de C¿1-4? alkylacétate contenant (R)-lansoprazole ou (S)-lansoprazole dans une concentration de 0,1 g/mL à 0,5 g/mL environ et similaires, à une température de 0 ·C à 35·C environ. Le procédé de fabrication selon l'invention permet de produire à échelle industrielle un cristal de (R)-lansoprazole ou de (S)-lansoprazole présentant une meilleure stabilité de conservation.

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