Process for the cyanation of aldehydes

Details Process for the cyanation of aldehydes Process for the cyanation of aldehydes

C - Chemistry, Metallurgy

07

C

C07C 253/00 (2006.01) B01J 31/18 (2006.01) C07B 53/00 (2006.01) C07C 255/14 (2006.01) C07C 255/15 (2006.01) C07C 255/38 (2006.01)

Patent

CA 2418116

A process for cyanating an aldehyde is provided. The process comprises reacting the aldehyde with: i) a cyanide source which does not comprise a Si- CN bond or a C-(C=O)-CN moiety; and ii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group; in the presence of a chiral catalyst. Preferably, the chiral catalyst is a chiral vanadium or titanium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride.

L'invention concerne un procédé de production de cyanhydrines à partir d'aldéhyde. Ce procédé consiste à faire réagir l'aldéhyde avec i)une source de cyanure qui ne comprend pas de liaison Si-CN ou une entité C-(C=O)-CN, et ii) un substrat susceptible d'attaque nucléophile ne comprenant pas d'halogène partant, en présence d'un catalyseur chiral. Le catalyseur chiral est, de préférence, un catalyseur chiral au titane ou au vanadium. La source de cyanure est, de préférence, un cyanure de métal alcalin et le substrat, susceptible d'attaque nucléophile et ne comprenant pas de groupe halogène partant, est un anhydride carboxylique.

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