G - Physics – 01 – N
Patent
G - Physics
01
N
167/44
G01N 33/543 (2006.01) G01N 33/563 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)
Patent
CA 1244761
Abstract The present invention provides a process for determining a polyvalent antigen by incubation with three different receptors, the first and third of which are present in liquid phase and with which the antigen is bindable, the second receptor is present in solid phase and is only bindable with a part of the first receptor and the third receptor carries a marking and does not cross-react with the first and second receptor, separ- ation of the solid phase. From the fluid phase and measurement of the marking in one of the phases, wherein a solution containing the antigen is brought together with a first solid carrier material, which contains, impreg- nated or lyophilised, the first and the third receptor in removable form and, after removal of the receptors, the solution obtained is immediately contacted with a second solid carrier material which contains a second receptor in non-removable form, whereafter the liquid is separated from the second solid carrier material and the marking is measured. The present invention also provides a dry reagent for determining a polyvalent antigen comprising a) a first solid carrier material impregnated or lyophilised. with two different soluble receptors 1 and 3, bindable with the antigen, of which receptor 3 carrier a marking, and b) a second solid carrier material, which is present physically separated from the first carrier material, the second solid carrier material containing an insoluble second receptor only bindable with a part of the non- marked soluble first receptor, with the proviso that the marked third receptor is a Fab fragment,
471361
Baier Manfred
Kleemann Wolfgang
Klose Sigmar
Pasch Manfred
Schlumberger Helmut
Boehringer Mannheim G.m.b.h.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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