Process for the development of binding mini-proteins

Details Process for the development of binding mini-proteins Process for the development of binding mini-proteins

C - Chemistry, Metallurgy

40

B

C40B 40/02 (2006.01) C07K 7/06 (2006.01) C07K 14/005 (2006.01) C07K 14/435 (2006.01) C07K 19/00 (2006.01) C12N 7/01 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12Q 1/70 (2006.01) C40B 30/04 (2006.01) C40B 40/08 (2006.01) C40B 40/10 (2006.01)

Patent

CA 2105300

Genes encoding disulfide-bonded micro-proteins and metal ion-coordinated mini- proteins are semi-randomly mutagenized and expressed in suitable cells so as to result in the simultaneous display of the different mutant proteins on the surfaces of bacterial cells, spores or phage; the resulting display library is screened for members having the ability to bind to a target of interest.

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