Process for the enantioselective preparation of...

Details Process for the enantioselective preparation of... Process for the enantioselective preparation of...

C - Chemistry, Metallurgy

07

C

C07C 271/22 (2006.01) C07C 231/18 (2006.01) C07C 233/87 (2006.01) C07C 269/06 (2006.01) C07D 305/14 (2006.01) C07D 309/12 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2079314

Process for the enantioselective preparation of phenylisoserin derivatives of general formula (I) from phenylglycine S(+). In the general formula (I), R is a phenyl radical or tert.butoxy and R1 is an alcohol function protective group. The products of general formula (I) can be used in the synthesis of taxane derivatives having an antitumoral and antileukemic activity.

2079314 9117976 PCTABS00106 Procédé de préparation énantiosélective de dérivés de la phénylisosérine de formule générale (I) à partir de la phénylglycine-S(+). Dans la formule générale (I), R représente un radical phényle ou tert.butoxy et R1 représente un groupement protecteur de la fonction alcool. Les produits de formule générale (I) sont utilisables dans la synthèse de dérivés du taxane ayant une activité antitumorale et antileucémique.

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