C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/19 (2006.01) C07K 14/28 (2006.01) C07K 14/535 (2006.01) C07K 14/54 (2006.01) C07K 14/55 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 9/12 (2006.01) C12N 9/52 (2006.01) C12N 15/27 (2006.01) C12P 21/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2074943
For the enzymatic cleavage of fusion proteins and for the isolation of desired components of these fusion proteins (1) a junction region, in which two components of the fusion protein are joined together, is modified by means of genetic engineering so that at least one IgA protease recognition site with the amino acid sequence Y-Pro~!~X-Pro is formed in this junction region, in which X can be any amino acid and Y can be one or several arbitrary amino acids, (2) the fusion protein which results from step (1) is cleaved by IgA protease at the position in the recognition site marked with ~!~ and (3) after the cleavage one or several desired components of the fusion protein are isolated.
Dony Carola
Meyer Thomas F.
Pohlner Johannes
Schumacher Guenter
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.v.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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