Process for the enzymatic preparation of grf(1-44)nh2

Details Process for the enzymatic preparation of grf(1-44)nh2 Process for the enzymatic preparation of grf(1-44)nh2

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) C07K 14/60 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2057269

Abstract GRF(1-44)-NH2 is prepared by the trypsin catalyzed enzymatic coupling of Leu-NH2 to GRF(1-43)-OH. The latter compound may be obtained by recombinant DNA synthesis. Thus the present method provides an economical way to obtain the clinically important GRF(1- 44)-NH2.

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