Process for the enzymatic preparation of optically active...

Details Process for the enzymatic preparation of optically active... Process for the enzymatic preparation of optically active...

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) C07D 223/16 (2006.01) C07D 281/02 (2006.01) C07D 303/48 (2006.01) C12P 17/02 (2006.01)

Patent

CA 2111595

The invention relates to the preparation of an optically active ester of trans-3-phenylglycidic acid in which a mixture of the 2 enantiomers of the trans-3-phenylglycidic acid ester is stereoselectively hydrolyzed using an enzyme originating from Candida antarctica and the non-hydrolyzed eater is separated off from the reaction mixture. A racemic mixture of trans-phenylglycidic acid esters is selectively and enzymatically hydrolyzed in a relatively short reaction time, the residual ester being obtained in a high yield and with a high e.e. Such esters are used for the preparation of pharmaceuticals such as benzothiazepines and benzazepines.

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