Process for the enzymatic synthesis of .beta.-lactam...

Details Process for the enzymatic synthesis of .beta.-lactam... Process for the enzymatic synthesis of .beta.-lactam...

C - Chemistry, Metallurgy

12

P

C12P 37/04 (2006.01) A61K 31/43 (2006.01) A61K 31/545 (2006.01) C12N 9/84 (2006.01) C12P 35/04 (2006.01)

Patent

CA 2168923

Disclosed is a process for producing penicillins or cephalosporins by reacting an amino group of impure 6--aminopenicillanic acid or 7-aminocephalosporanic acid with an amide of the formula (see above formula) in which R is an optionally substituted 6-membered hydrocarbon ring and R2 and R3 are each hydrogen or lower alkyl. The reaction is catalyzed by a penicillin acylase enzyme and takes place in the presence of enzyme inhibitors that are naturally contained in the impure 6-aminopenicillanic acid or 7-aminocephalosporanic acid.

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